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Updated: May 24, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Multistage bone-charged distraction osteogenesis for aesthetic reconstruction of an extensive bone deficiency in the
Yorikatsu Watanabe1, Ryo Sasaki, Tomohiro Ando
1Department of Plastic, Reconstructive and Aesthetic Surgery, Tokyo Metropolitan Police Hospital, and Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. yorika2@hotmail.com
Abstract:
Alveolar and mandibular bone defects impair occlusion and affect the aesthetics of facial contouring, making it difficult to obtain a satisfactory outcome. Treatment with distraction osteogenesis (DO) is particularly difficult in cases in which the defective region extends to close to the inferior margin of the mandible. To overcome the limits of current DO, we developed a method as follows. In the first stage, a submucosal space necessary for bone grafting was prepared by soft tissue expansion through DO. In the second stage, an iliac corticocancellous bone was transplanted with its cancellous side in close contact with the new bone in the space formed on the labial side into this new space. In the third stage, the grafted bone was distracted. This technique requires time, but each surgery is of minimum invasiveness and does not leave a visible scar; use of this technique may expand the limited indication of current DO and dental implants.
