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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Peripheral ossifying fibroma.

Eloá R Luvizuto1, Jorge B G Da Silva, Gisele C R Luvizuto

  • 1Department of Surgery and Integrated Clinic, Araçatuba Dental School, UNESP-Universidade Estadual Paulista, São Paulo, Brazil. eloa@foa.unesp.br

The Journal of Craniofacial Surgery
|February 17, 2012
PubMed
Summary

Peripheral ossifying fibroma (POF), a common gingival growth, was successfully treated with excisional biopsy and connective tissue grafting. This approach ensured satisfactory defect repair and prevented lesion recurrence over six years.

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Area of Science:

  • Oral pathology
  • Periodontology
  • Oral surgery

Background:

  • Peripheral ossifying fibroma (POF) is a common gingival lesion, often originating from the interdental papilla, particularly in the anterior maxilla.
  • The exact etiology and pathogenesis of POF are debated, with theories suggesting neoplastic or reactive processes originating from periodontal ligament cells.
  • Potential contributing factors include trauma and local irritants like plaque, calculus, and ill-fitting dental prosthetics.

Observation:

  • Excisional biopsy is the standard treatment for POF.
  • This surgical procedure can result in a significant defect, necessitating further reconstructive measures.
  • A subepithelial connective tissue graft is a viable option for correcting post-biopsy defects.

Findings:

  • A clinical case demonstrated the successful excision of a POF.
  • The resulting biopsy defect was effectively managed using a subepithelial connective tissue graft.
  • The patient experienced no recurrence of the POF during a 6-year follow-up period.

Implications:

  • Combining excisional biopsy with subepithelial connective tissue grafting offers a predictable method for treating peripheral ossifying fibromas.
  • This combined approach ensures both lesion removal and aesthetic/functional defect reconstruction.
  • Long-term follow-up confirms the efficacy and stability of this treatment strategy for POF.