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TEMPO-mediated electrooxidation of primary and secondary alcohols in a microfluidic electrolytic cell
Joseph T Hill-Cousins1, Jekaterina Kuleshova, Robert A Green
1School of Chemistry, University of Southampton, Southampton, Hampshire, UK.
Abstract:
A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described. The electrocatalytic system utilises a buffered aqueous tert-butanol reaction medium, which operates effectively without the requirement for additional electrolyte, providing a mild protocol for the oxidation of alcohols to aldehydes and ketones at ambient temperature on a laboratory scale. Optimisation of the process is discussed along with the oxidation of 15 representative alcohols.
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