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Related Experiment Video

Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases

Protein Modifications: Protein Kinases and Phosphatases

Amoxicillin for acute rhinosinusitis: a randomized controlled trial.

Jane M Garbutt¹, Christina Banister, Edward Spitznagel

¹Division of General Medical Sciences, Washington University School of Medicine, Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA. jgarbutt@dom.wustl.edu

|February 17, 2012

Summary

This summary is machine-generated.

Amoxicillin did not significantly improve acute rhinosinusitis symptoms by day 3 compared to placebo. While some symptom improvement was noted by day 7, overall outcomes were similar, questioning routine antibiotic use.

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Last Updated: Feb 6, 2026

Protein Modifications: Protein Kinases and Phosphatases

Protein Modifications: Protein Kinases and Phosphatases

Regulated and Targeted Protein Degradation

Regulated and Targeted Protein Degradation

Covalently Linked Protein Regulators and Post-translational Modification

Covalently Linked Protein Regulators and Post-translational Modification

Area of Science:

Clinical Medicine
Infectious Diseases
Pharmacology

Background:

Antibiotic use for acute rhinosinusitis (ARS) is common despite limited evidence supporting its efficacy.
Understanding the incremental benefit of antibiotics over symptomatic treatment is crucial for clinical guidelines.

Purpose of the Study:

To evaluate the added benefit of amoxicillin versus placebo in adults diagnosed with acute rhinosinusitis.
To assess the impact of amoxicillin on quality of life and symptom resolution in ARS patients.

Main Methods:

A randomized, placebo-controlled trial involving 166 adults with clinically diagnosed acute rhinosinusitis.
Participants received a 10-day course of amoxicillin or placebo, alongside symptomatic treatments as needed.
Outcomes, including quality of life (Sinonasal Outcome Test-16) and symptom improvement, were assessed at multiple time points.

Main Results:

No significant difference in Sinonasal Outcome Test-16 scores between amoxicillin and placebo groups at day 3 or day 10.
A statistically significant improvement in symptom reporting was observed favoring amoxicillin at day 7 (P = .02).
No significant differences were found in other secondary outcomes, including recurrence, relapse, or adverse events.

Conclusions:

A 10-day course of amoxicillin did not demonstrate a significant benefit over placebo in reducing symptoms of acute rhinosinusitis by day 3.
The findings suggest that routine antibiotic prescription for acute rhinosinusitis may not be warranted, emphasizing the need for judicious antibiotic use.