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Published on: June 3, 2018
Detection of a possible bioterrorism agent, Francisella sp., in a clinical specimen by use of next-generation direct
Makoto Kuroda1, Tsuyoshi Sekizuka, Fumiaki Shinya
1Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan. makokuro@nih.go.jp
Abstract:
Deep sequencing detected a potential bioterrorism agent, Francisella tularensis, in a human abscess sample (Iwaki-08) of unknown etiology. Identified single-nucleotide variations suggest that the Iwaki-08 case was associated with Francisella tularensis subsp. holarctica (biovar japonica) but not the highly virulent type A (Francisella tularensis subsp. tularensis).
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