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Updated: May 24, 2026
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
[The role of Th17 cells in immune thrombocytopenia mice models]
Ting-ting Wang1, Hui-yuan Li, Zhao Wang
1Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Objective:
To investigate the role of Th17 cells in immune thrombocytopenia (ITP) mice model.
Method:
ITP was induced by daily intraperitoneal injection of anti-platelet membrane CD41 antibody (MWReg30) into BALB/c mice, the mRNA expressions of Th17 cell associated transcription factors and cytokines in peripheral blood and spleen mononuclear cells were measured by real-time PCR, and the proportion of Th17 cells by FCM analysis.
Results:
The percentage of Th17 cell was significantly elevated in ITP mice both in splenocyte and peripheral blood as compared with that in normal controls (P<0.01). ITP mice had elevated mRNA expressions of IL-17F, IL-17A and IL-6 in splenocyte (P<0.05), and of IL-21 in peripheral blood (P<0.05). There was a positive correlation between IL-17A and IL-17F (r = 0.934, P = 0.000), and between IL-17A/IL-17F and IL-6 (r = 0.598, P = 0.001; r = 0. 619, P = 0.000).
Conclusions:
Th17 cell might play an important role in the pathogenesis of ITP, at least involving in the clearance of platelets.
