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Updated: May 24, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Juvenile xanthogranuloma: 3 cases report and literature review]
Zi-qin Liu1, Rong Liu, Xiao-dong Shi
1The Department of Hematology and Oncology of Capital Institute of Pediatrics, Beijing 100020, China.
Objective:
To report the clinical characteristics and treatment of 3 patients with juvenile xanthogranuloma (JXG).
Methods:
A retrospective review of the medical records of 3 patients with JXG.
Results:
JXG was characterized by solitary or multiple yellowish cutaneous nodules, or eye involvement . It could also affect pituitary. JXG was easily misdiagnosed as Langerhans cell histiocytosis (LCH). Treatment for JXG was surgical excision of a solitary skin lesion and some cases might be, spontaneous regression. In cases with multisystem involvement, chemotherapy regimens used to treat LCH may be effective.
Conclusions:
JXG is one of the more common non-Langerhans histiocytic proliferations and is frequently seen in infants and children. LCH-like chemotherapy is effective for patients with symptomatic multisystem JXG.
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