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Evaluation of the mutagenic potential of endosulfan using the Salmonella/mammalian microsome assay
N Pandey1, F Gundevia, P K Ray
1Environmental Microbiology Section, Industrial Toxicology Research Centre, Lucknow, India.
Mutation Research
|October 1, 1990
Abstract:
The mutagenic potential of endosulfan, a polychlorinated insecticide, was assessed using the highly sensitive Salmonella tester strains TA97(a), TA98, TA100 and TA102. It exhibited a toxic effect at dose levels of 50 micrograms/plate and higher. Plate incorporation studies did not show mutagenic response with any of the tester strains used. A modification of the assay using a preincubation procedure showed mutagenic activity with and without metabolic activation with TA97(a) only. Increased toxicity was observed after addition of phenobarbital-induced S9 mix.