Related Experiment Videos
Methyl vinyl sulphone: a new class of Michael-type genotoxin
T J Warr1, J M Parry, R D Callander
1School of Biological Sciences, University College of Swansea, Singleton Park, Great Britain.
Mutation Research
|November 1, 1990
Abstract:
Methyl vinyl sulphone (MVS) is a labile, Michael-reactive chemical, similar in structure to acrylamide (AA). Given that acrylamide is a reference mammalian mutagen and a rodent carcinogen, studies were undertaken to evaluate the potential genotoxicity of MVS. In common with AA, MVS was non-mutagenic to Salmonella but active as an aneugen to cultured mammalian cells. It is concluded that vinyl sulphones should be regarded as representative of a new class of genotoxic chemical whose mode of action is probably primarily dependent upon Michael reactivity to proteins.