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Changes in the retrobulbar arterial circulation after decrease of elevated intraocular pressue in patients with
Ivan Marjanović1, Ana Sundić, Milija Mijajlović
1Clinic of Eye Diseases, Clinical Centre of Serbia, Pasterova 2 St, 11000 Belgrade. ivanmarjanovic007@yahoo.com
Srpski Arhiv Za Celokupno Lekarstvo
|February 18, 2012
Summary
Lowering intraocular pressure in primary open angle glaucoma patients alters retrobulbar arterial circulation. These hemodynamic changes highlight the role of vascular factors in glaucoma progression and neuroprotection.
Area of Science:
- Ophthalmology
- Vascular Biology
- Glaucoma Research
Background:
- Altered optic nerve head perfusion is a suspected factor in glaucoma pathogenesis.
- Understanding vascular contributions is crucial for managing glaucoma progression.
Purpose of the Study:
- To assess hemodynamic changes in retrobulbar arteries after reducing intraocular pressure (IOP) in primary open angle glaucoma (POAG) patients.
- To investigate the relationship between IOP reduction and ocular blood flow dynamics.
Main Methods:
- Color Doppler imaging was used to measure hemodynamic parameters (PSV, EDV, RI, PI) in the ophthalmic artery, central retinal artery, and posterior ciliary arteries.
- Intraocular pressure was measured using Goldmann applanation and dynamic contour tonometry.
- Central corneal thickness was assessed via ultrasound pachymetry in 26 POAG patients.
Main Results:
- Following IOP reduction, ophthalmic and central retinal arteries showed decreased peak systolic velocity (PSV) and end-diastolic velocity (EDV), with increased resistive index (RI) and pulsatility index (PI).
- Posterior ciliary arteries exhibited lower PSV, EDV, and PI, alongside a higher RI after IOP decrease.
Conclusions:
- Hemodynamic alterations in retrobulbar circulation following IOP reduction in POAG patients are significant for treatment strategies.
- Vascular factors influencing optic disc neuroretinal rim perfusion may be key to mitigating glaucoma progression and enabling neuroprotection.
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