Central changes in hypothyroid myopathy: a case report
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R M Evans1, I Watanabe, P A Singer
1Neurology Service, Veterans Administration Medical Center, Kansas City, MO 64128.
Muscle & Nerve
|October 1, 1990
Abstract:
A muscle biopsy from a patient with hypothyroid myopathy showed striking central changes. "Cores" were seen in most type 1 fibers with oxidative enzyme preparations. Electron microscopy of these areas revealed Z disc streaming, myofilament disruption, and absent mitochondria. The myopathy rapidly improved with thyroxine treatment. This biopsy is of interest, as numerous "cores" have not previously been reported in hypothyroid myopathy.