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Related Experiment Videos

Central changes in hypothyroid myopathy: a case report.

R M Evans1, I Watanabe, P A Singer

  • 1Neurology Service, Veterans Administration Medical Center, Kansas City, MO 64128.

Muscle & Nerve
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Hypothyroid myopathy can cause central "cores" in muscle fibers, a finding not previously reported. Treatment with thyroxine (thyroid hormone) led to rapid improvement in muscle function.

Area of Science:

  • Neurology
  • Endocrinology
  • Muscle Biology

Background:

  • Hypothyroid myopathy is a neuromuscular disorder associated with hypothyroidism.
  • Muscle biopsy findings in hypothyroid myopathy typically include non-specific changes.

Observation:

  • A muscle biopsy from a patient with hypothyroid myopathy revealed significant central changes in type 1 muscle fibers.
  • These changes included the presence of numerous "cores" when examined with oxidative enzyme preparations.

Findings:

  • Electron microscopy confirmed Z disc streaming, myofilament disruption, and absence of mitochondria within these "cores".
  • This observation of numerous "cores" is novel in the context of hypothyroid myopathy.

Implications:

Related Experiment Videos

  • The presence of "cores" in hypothyroid myopathy expands the spectrum of histopathological findings in this condition.
  • Rapid improvement of myopathy symptoms with thyroxine treatment highlights the direct impact of thyroid hormone on muscle structure and function.