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Updated: May 24, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Prevalence, prognosis, and factors associated with left ventricular diastolic dysfunction in systemic sclerosis
Monique Hinchcliff1, Chintan S Desai, John Varga
1Northwestern University Feinberg School of Medicine, Chicago, IL, USA. m-hinchcliff@northwestern.edu
Clinical and Experimental Rheumatology
|February 18, 2012
Summary
Left ventricular diastolic dysfunction affects 23% of systemic sclerosis (SSc) patients, linked to disease duration and increased mortality risk. Early detection is crucial for managing this SSc complication.
Area of Science:
- Cardiology
- Rheumatology
- Echocardiography
Background:
- Systemic sclerosis (SSc) can affect cardiac function.
- Left ventricular (LV) diastolic dysfunction is a potential complication in SSc patients.
Purpose of the Study:
- To investigate the prevalence of LV diastolic dysfunction in SSc.
- To identify clinical factors associated with LV diastolic dysfunction.
- To assess the prognostic significance of LV diastolic dysfunction in SSc.
Main Methods:
- 153 SSc patients were assessed for LV diastolic dysfunction using lateral tissue Doppler E' velocity.
- Clinical, laboratory, pulmonary function, and echocardiographic data were compared.
- Multivariable regression analyses identified factors associated with LV diastolic dysfunction and mortality risk.
Main Results:
- LV diastolic dysfunction was found in 23% of SSc patients; LV systolic dysfunction in 5.2%.
- Associated factors included SSc disease duration, age, coronary artery disease, and hypertension.
- LV diastolic dysfunction independently predicted increased mortality risk (HR 3.2).
Conclusions:
- LV diastolic dysfunction is common in SSc.
- Disease duration is a key associated factor.
- LV diastolic dysfunction serves as a significant marker for increased mortality risk in SSc.
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