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Related Experiment Video

Updated: May 24, 2026

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
07:52

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts

Published on: April 26, 2018

Fluorescence-guided malignant glioma resections.

Ranjith Babu1, David Cory Adamson

  • 1Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.

Current Drug Discovery Technologies
|February 21, 2012
PubMed
Summary

Fluorescence-guided surgery improves glioma resection by clearly defining tumor margins. This technique enhances extent of resection, progression-free survival, and overall survival for brain tumor patients.

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Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
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Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

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Last Updated: May 24, 2026

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
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Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

Area of Science:

  • Neurosurgery
  • Oncology
  • Medical Imaging

Background:

  • Gliomas are primary brain tumors with poor outcomes, especially high-grade types.
  • Complete surgical resection is challenging due to the infiltrative nature of malignant gliomas and unclear tumor margins.

Purpose of the Study:

  • To review exogenous and endogenous fluorescence techniques for intraoperative glioma margin delineation.
  • To assess the impact of fluorescence-guided surgery on resection extent and patient survival.

Main Methods:

  • Review of clinical trials and preclinical studies on fluorescence agents (e.g., aminolevulinic acid, fluorescein) and technologies (e.g., fluorescence spectroscopy).
  • Evaluation of fluorescence-guided resection's efficacy in increasing the extent of tumor removal.

Main Results:

  • Aminolevulinic acid and fluorescein have demonstrated increased extent of resection, progression-free survival, and overall survival.
  • Endogenous fluorescence techniques, like spectroscopy, offer margin delineation without exogenous agents.
  • Nanoparticles are under preclinical investigation for future applications.

Conclusions:

  • Fluorescence-guided resection is a promising technique to improve surgical outcomes for glioma patients.
  • This approach enhances the quality of surgery and is expected to become a standard of care.