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Updated: May 24, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
Published on: July 18, 2019
Convection enhanced delivery of macromolecules for brain tumors
Ankit I Mehta1, Bryan D Choi, Divya Ajay
1Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA. ankit.mehta@duke.edu
Abstract:
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

