Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
The Bronchial Tree01:23

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of preterm birth with severity of molecularly-confirmed acute viral respiratory illness presenting to the emergency department: a multi-year analysis.

Frontiers in pediatrics·2026
Same author

Serum Phosphorus and Hypophosphatemia During Therapy of Diabetic Ketoacidosis in Children: Single-Center, Retrospective Cohort 2016-2022.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2025
Same author

Radiographic changes in ribs following clipping of patent ductus arteriosus in preterm infants.

SAGE open medicine·2022
Same author

The Two-bag System for Intravenous Fluid Management of Children with Diabetic Ketoacidosis: Experience from a Community-Based Hospital.

Global pediatric health·2021
Same author

Pulmonary tuberculosis outbreak in a pediatric population.

Clinical pediatrics·2013
Same author

Sleep disorders in children: a national assessment of primary care pediatrician practices and perceptions.

Pediatrics·2011
Same journal

Rare Forms of Abdominal Wall Defects: A Case Series.

Fetal and pediatric pathology·2026
Same journal

Copy Number Variants in Prenatal Diagnosis: A Study on Genetic Origins, Follow-up, and Dynamic Clinical Interpretation.

Fetal and pediatric pathology·2026
Same journal

Brain Structural and Dysmaturation Anomalies in First- and Second-Trimester Trisomy 21 Fetuses: Ultrasound, MRI, and Autopsy Findings.

Fetal and pediatric pathology·2026
Same journal

Clinical Pathological Features and Cytokeratin Expression Patterns of Osteofibrous Dysplasia in Children.

Fetal and pediatric pathology·2026
Same journal

A Case of Epstein-Barr Virus Associated Smooth Muscle Tumor in the Bronchus of a Child with <i>CARMIL2</i> Deficiency and a Literature Review.

Fetal and pediatric pathology·2026
Same journal

PANoptosis Genes as Novel Diagnostic Biomarkers for Neonatal Necrotizing Enterocolitis.

Fetal and pediatric pathology·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Plastic bronchitis in children.

Rashed A Hasan1, Craig Black, Ramalinga Reddy

  • 1Mercy Children's Hospital, Pediatric Intensive Care Unit, Toledo, Ohio 43608, USA. rashedh48@gmail.com

Fetal and Pediatric Pathology
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Plastic bronchitis (PB) is a rare childhood disorder causing airway obstruction due to cast formation. Bronchoscopic removal of major cast segments in two children with PB was linked to positive outcomes, offering a potential treatment approach.

Related Experiment Videos

Last Updated: May 24, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pediatric Pulmonology
  • Pathology

Background:

  • Plastic bronchitis (PB) is a rare condition in children characterized by the formation of bronchial casts leading to airway obstruction.
  • The disorder is uncommon, and understanding its presentation and effective management is crucial.

Observation:

  • This report details two pediatric cases of plastic bronchitis.
  • Both cases occurred in the context of an apparent lower respiratory tract infection.
  • Bronchoscopic removal of significant cast segments was performed.

Findings:

  • Bronchoscopic intervention and cast removal were associated with favorable clinical outcomes in both patients.
  • The study presents the clinical, radiographic, and histopathologic features of the bronchial casts.
  • Detailed gross anatomic and histopathologic analysis of the removed casts is provided.

Implications:

  • Bronchoscopic removal of bronchial casts may be an effective treatment for pediatric plastic bronchitis.
  • This approach offers a potential therapeutic strategy for this rare but serious condition.
  • Further research into the underlying mechanisms and optimal management of PB is warranted.