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Updated: May 24, 2026

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
Published on: October 31, 2017
Current and future microbicide approaches aimed at preventing HIV infection in women
Bruno Pozzetto1, Olivier Delézay, Amandine Brunon-Gagneux
1Groupe Immunité des Muqueuses et Agents Pathogènes, PRES de Lyon, Université Jean Monnet, IFRESIS et CHU de Saint-Etienne, 42023 Saint-Etienne cedex 02, France. bruno.pozzetto@univ-st-etienne.fr
Abstract:
Women from developing countries, in which the prevalence of HIV infection is very high, are at risk of becoming infected without having the possibility of personally controlling this risk. Therefore, there is an urgent need to develop anti-HIV vaginal microbicide strategies. This review considers the modes of entry of HIV through the mucosa of the female genital tract, the different classes of vaginal microbicide compounds, the mode of delivery of these drugs, the aims and methods of in vitro and animal experiments at the preclinical stage, the results of the Phase III trials conducted in different countries, including the ongoing assays, and the future orientations for the next 5 years with a discussion relative to antiviral resistance, combination strategies and development of new-generation compounds.
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