Related Experiment Video

Updated: May 24, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Published on: July 31, 2021

Different clinical manifestation of cow's milk allergy in two preterm twins newborns

Caterina Coviello1, Dhyana Chiara Rodriquez, Sara Cecchi

  • 1Department of Pediatrics, Obstetrics and Reproductive Medicine, Neonatal Pediatrics Section, University Hospital of Siena, Italy.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|February 21, 2012
PubMed

Insights

Cow's milk allergy (CMA) affects 2-7% of infants. This study highlights two preterm twins with CMA presenting with different gastrointestinal issues, including NEC-like symptoms, emphasizing early diagnosis and varied clinical presentations.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Neonatology

Background:

  • Cow's milk protein allergy (CMA) incidence is rising in newborns, including premature infants.
  • Adverse reactions to cow's milk affect 2-7% of infants within their first year.
  • Early-onset CMA poses diagnostic challenges in the neonatal population.

Observation:

  • Two cases of early-onset CMA in preterm twins are presented.
  • One twin experienced recurrent proctocolitis, while the other had two necrotizing enterocolitis (NEC)-like episodes.
  • Clinical presentations varied significantly between the twins despite the same underlying condition.

Findings:

  • The cases illustrate diverse clinical manifestations of cow's milk protein allergy.
  • Recurrent enterocolitis episodes were associated with increasing systemic eosinophilia.
  • Symptoms clinically and radiologically mimicked NEC, complicating diagnosis.

Implications:

  • Highlights the importance of considering CMA in preterm infants with gastrointestinal distress.
  • Suggests eosinophilia as a potential marker for CMA in this population.
  • Underscores the need for heightened awareness of varied CMA presentations mimicking surgical emergencies like NEC.

More Related Videos

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Cross-reactivity00:42

Cross-reactivity

Overview
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...