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Related Concept Videos

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...

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Role of Protein L25 and Its Contact with Protein L16 in Maintaining the Active State of Escherichia coli Ribosomes in vivo.

Biochemistry. Biokhimiia·2016
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Mutant forms of Escherichia coli protein L25 unable to bind to 5S rRNA are incorporated efficiently into the ribosome in vivo.

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Ribosomal proteins: structure, function, and evolution.

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Bacterial 5S rRNA-binding proteins of the CTC family.

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Protein CTC from Aquifex aeolicus possesses a full-sized 5S rRNA-binding domain.

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Related Experiment Video

Updated: May 24, 2026

Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis
08:07

Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis

Published on: July 6, 2021

5S rRNA and ribosome.

G M Gongadze1

  • 1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. gongadze@vega.protres.ru

Biochemistry. Biokhimiia
|February 21, 2012
PubMed
Summary

5S ribosomal RNA (rRNA) is essential for ribosome function. This review explores its history, structure, and proposed roles, suggesting it acts as an intermediary between ribosome domains.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • 5S ribosomal RNA (rRNA) is a crucial component of ribosomes in all organisms.
  • Ribosomes lacking 5S rRNA are functionally inactive, highlighting its importance.
  • The precise function of 5S rRNA in translation remains incompletely understood.

Purpose of the Study:

  • To review the discovery, origin, and localization of 5S rRNA.
  • To discuss historical and current hypotheses regarding the role of 5S rRNA.
  • To propose a model for 5S rRNA function based on its ribosomal location and interactions.

Main Methods:

  • Literature review of historical and recent studies on 5S rRNA.
  • Analysis of existing data on ribosome structure and functional complexes.

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Eukaryotic Polyribosome Profile Analysis

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Last Updated: May 24, 2026

Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis
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  • Integration of structural and functional information to infer RNA roles.

    • Main Results:

    • 5S rRNA's unique position within the ribosome suggests a specific role.
    • Intermolecular contacts of 5S rRNA provide clues to its function.
    • Current data supports 5S rRNA's involvement in coordinating ribosome domains.

    Conclusions:

    • 5S rRNA is vital for ribosome assembly and function.
    • Its specific role likely involves mediating interactions between different ribosomal regions.
    • Further research into 5S rRNA's dynamic interactions is warranted.