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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Related Experiment Video

Updated: May 24, 2026

Heterotopic Auxiliary Whole Liver Rat Transplant Model Utilizing a Hepaticoureterostomy for Allograft Rejection Studies
11:25

Heterotopic Auxiliary Whole Liver Rat Transplant Model Utilizing a Hepaticoureterostomy for Allograft Rejection Studies

Published on: March 8, 2024

ABO-incompatible organ transplantation.

V Subramanian1, S Ramachandran, C Klein

  • 1Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

International Journal of Immunogenetics
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

ABO-incompatible organ transplants are increasingly viable, especially in infants, offering a solution to organ shortages. This approach can reduce wait times and improve patient outcomes in kidney and pediatric heart transplants.

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Orthotopic Hind Limb Transplantation in the Mouse
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Orthotopic Hind Limb Transplantation in the Mouse

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: May 24, 2026

Heterotopic Auxiliary Whole Liver Rat Transplant Model Utilizing a Hepaticoureterostomy for Allograft Rejection Studies
11:25

Heterotopic Auxiliary Whole Liver Rat Transplant Model Utilizing a Hepaticoureterostomy for Allograft Rejection Studies

Published on: March 8, 2024

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Transplantation immunology
  • Organ transplantation
  • Immunosuppression

Background:

  • Growing organ transplant waitlists exceed organ availability, leading to increased patient morbidity and mortality.
  • Extended criteria donors and ABO-incompatible organs are now being utilized to address organ shortages.
  • Conventional immunosuppression shows promising results for ABO-incompatible grafts, comparable to ABO-compatible transplants.

Purpose of the Study:

  • To review the current status of ABO-incompatible transplantation in adult and pediatric solid organ transplantation.
  • To highlight recent advancements in understanding graft acceptance mechanisms in ABO-incompatible organs.
  • To discuss the potential of ABO-incompatible transplantation to alleviate organ shortages and reduce waitlist times.

Main Methods:

  • Review of current literature on ABO-incompatible solid organ transplantation.
  • Analysis of outcomes in adult and pediatric ABO-incompatible transplants.
  • Examination of immunological mechanisms underlying graft acceptance in ABO-incompatible settings.

Main Results:

  • Infants possess an 'immunological window' due to delayed ABO antigen antibody development, enabling successful ABO-incompatible transplants and potential long-term graft tolerance.
  • ABO incompatibility is increasingly recognized as a viable option, not a contraindication, for kidney and pediatric heart transplantation.
  • Increased utilization of ABO-incompatible grafts can significantly decrease organ waitlist times and associated morbidity.

Conclusions:

  • ABO-incompatible transplantation is a critical strategy to mitigate organ shortages and reduce waitlist mortality.
  • The immunological characteristics of infants facilitate successful ABO-incompatible transplants and long-term graft acceptance.
  • Further research into the mechanisms of graft acceptance will enhance the application of ABO-incompatible organs in transplantation.