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Related Concept Videos

Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Corrigendum to "Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024)" [The Lancet Regional Health-Southeast Asia Volume 50, July 2026, 100794].

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Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024).

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Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Dementia prevention: current epidemiological evidence and future perspective.

Francesca Mangialasche1, Miia Kivipelto, Alina Solomon

  • 1Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI)-Stockholm University, Gävlegatan 16 (9th floor) SE-113 30, Stockholm, Sweden. francesca.mangialasche@ki.se.

Alzheimer'S Research & Therapy
|February 21, 2012
PubMed
Summary

Preventing dementia involves addressing modifiable risk factors throughout life. Multidomain interventions combining lifestyle changes and managing vascular risks show promise for delaying cognitive decline and Alzheimer

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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Related Experiment Videos

Last Updated: May 24, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Area of Science:

  • Neuroscience
  • Epidemiology
  • Public Health

Background:

  • Dementia, including Alzheimer's disease (AD), is a significant public health concern, primarily caused by vascular and neurodegenerative damage.
  • While no cure exists, epidemiological studies identify modifiable risk and protective factors influencing dementia onset across the life course.

Purpose of the Study:

  • To explore evidence-based strategies for preventing or delaying the onset of dementia and AD.
  • To highlight the importance of multidisciplinary research and randomized controlled trials (RCTs) in confirming preventive measures.

Main Methods:

  • Review of epidemiological evidence on life-course risk and protective factors for dementia.
  • Analysis of ongoing multidomain interventional RCTs in Europe focusing on vascular risk management and cognitive reserve enhancement.
  • Initiation of the European Dementia Prevention Initiative for international collaboration.

Main Results:

  • Vascular risk factors significantly contribute to cognitive decline and dementia progression.
  • Engaging in social, physical, and mentally stimulating activities may delay dementia onset.
  • Multidomain intervention programs integrating lifestyle and medical management are a promising prevention strategy.

Conclusions:

  • Implementing life-course, multifactorial intervention programs is crucial for dementia prevention.
  • Ongoing RCTs and international collaborations like the European Dementia Prevention Initiative are vital for generating robust evidence for dementia and AD prevention strategies.