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Related Experiment Video

Updated: May 24, 2026

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

Mouse transgenic approaches in optogenetics.

Hongkui Zeng1, Linda Madisen

  • 1Allen Institute for Brain Science, Seattle, WA, USA. hongkuiz@alleninstitute.org

Progress in Brain Research
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

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Optogenetics allows precise control of genetically defined brain cells using light. This technique is revolutionizing neuroscience research by enabling detailed study of neural circuits and their role in behavior.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Understanding brain function requires studying complex neural networks.
  • Traditional methods like gene manipulation or lesions lack spatial and temporal precision.
  • Optogenetics offers a novel solution for precise neural circuit analysis.

Purpose of the Study:

  • To review advancements in optogenetic tools for neuroscience.
  • To discuss the generation of transgenic mice expressing optogenetic tools.
  • To identify areas for technological improvement in optogenetics.

Main Methods:

  • Utilizing optogenetics to monitor and manipulate genetically defined cell populations.
  • Employing transgenic mice engineered for cell type-specific optogenetic tool expression.

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Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
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Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
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Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

Related Experiment Videos

Last Updated: May 24, 2026

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

  • Analyzing the functional roles of specific cells within neural circuits.

    • Main Results:

    • Optogenetics provides high speed and precision in studying neural activity.
    • Transgenic mouse lines enable cell-specific circuit investigation.
    • Significant efforts have been made to generate effective optogenetic tool-expressing mouse lines.

    Conclusions:

    • Optogenetics is a powerful tool for dissecting neural circuits.
    • Transgenic mouse models are crucial for cell type-specific optogenetic studies.
    • Further technological development is needed to enhance optogenetic capabilities.