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Plasma soluble triggering receptor expressed on myeloid cells-1 in Crohn's disease

Vincent Billioud1, Sébastien Gibot, Frédéric Massin

  • 1INSERM U954, Université Henri Poincaré 1, Vandoeuvre-lès-Nancy, France.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|February 21, 2012
PubMed

Insights

Plasma soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is not an accurate marker for assessing Crohn's disease activity. This study found no correlation between sTREM-1 levels and established disease activity indices in Crohn's disease patients.

Area of Science:

  • Gastroenterology
  • Immunology
  • Biomarker Discovery

Background:

  • Existing data lacks definitive conclusions on the accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for assessing Crohn's disease activity.
  • sTREM-1 is a potential biomarker for inflammatory conditions.

Purpose of the Study:

  • To investigate the correlation between plasma sTREM-1 levels and established disease activity markers in Crohn's disease patients.
  • To determine if sTREM-1 can serve as a reliable indicator of disease severity in Crohn's disease.

Main Methods:

  • Prospective enrollment of 191 consecutive Crohn's disease patients and 20 healthy controls.
  • Measurement of plasma sTREM-1 levels.
  • Correlation analysis with Crohn's disease activity index (CDAI), C-reactive protein (CRP), and albumin levels.

Main Results:

  • Plasma sTREM-1 was detectable in 46% of Crohn's disease patients and was significantly higher than in healthy controls (P=0.01).
  • No significant correlation was found between plasma sTREM-1 levels and CDAI (r=0.05, P=0.56), CRP (r=0.06, P=0.53), or albumin (r=-0.041, P=0.66).
  • sTREM-1 levels did not differ significantly between patients with positive and undetectable levels, nor were they influenced by common Crohn's disease medications.

Conclusions:

  • Plasma sTREM-1 is not an accurate biomarker for assessing disease activity in Crohn's disease.
  • sTREM-1 cannot be recommended for routine use in monitoring Crohn's disease activity.
Abstract

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