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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Olfactory function in patients with multiple sclerosis: a diffusion tensor imaging study.

Katharina Erb1, Georg Bohner, Lutz Harms

  • 1Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany. katharina.erb@charite.de

Journal of the Neurological Sciences
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis patients show impaired odour identification linked to white matter lesions in the olfactory brain. Diffusion tensor imaging reveals reduced fractional anisotropy in lesions, correlating with olfactory deficits.

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) is known to cause olfactory disturbances in patients.
  • Understanding the neural basis of these olfactory deficits is crucial for MS management.

Purpose of the Study:

  • To investigate the correlation between olfactory function and cerebral magnetic resonance imaging (MRI) findings in MS patients.
  • Specifically examining the relationship with diffusion tensor imaging (DTI) parameters.

Main Methods:

  • Olfactory performance (threshold, discrimination, identification - TDI score) was assessed in 30 MS patients and 30 controls.
  • Cerebral MRI, including PD- and T2-weighted images, quantified lesion load.
  • Diffusion tensor imaging (DTI) measured fractional anisotropy (FA) in white matter lesions and normal-appearing brain tissue (NABT).

Main Results:

  • MS patients exhibited significantly poorer normalised TDI and identification (I) scores compared to controls.
  • White matter lesions in MS showed reduced FA (median 0.29) compared to surrounding NABT.
  • Reduced FA in olfactory brain lesions inversely correlated with the odour identification (I) subscore (p=0.001).

Conclusions:

  • A significant inverse relationship exists between impaired odour identification and FA values in the olfactory brain of MS patients.
  • Lesions in areas with high FA values, indicating affected white matter tracts, are strongly associated with reduced odour identification ability.