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Published on: December 9, 2015
Serum prolactin level in patients with relapsing-remitting multiple sclerosis during relapse
Sasan Moshirzadeh1, Kourosh Ghareghozli, Ali Amini Harandi
1Department of Neurology, 31151 Shahid Beheshti University of Medical Sciences, Logman Hospital, South Kargar Avenue, Kamali Street, Makhsus Alley, Tehran 13336, Iran. Sasan_moshir@yahoo.com
Abstract:
It has been hypothesized that hyperprolactinemia may contribute to the pathogenesis of multiple sclerosis (MS). In a case-control study, 58 patients with definite relapsing-remitting MS (RRMS) during relapse and 58 sex-matched and age-matched healthy controls were assessed for serum prolactin (PRL) concentration. Mean serum PRL levels (± standard deviation) were significantly higher in patients with MS (501.3 ± 232.6 mIU/L) than in healthy control patients (233.3 ± 142.7 mIU/L; p < 0.0001). Furthermore, these differences were consistent in each sex: females with MS (704.4 ± 119.6 mIU/L) compared to female controls (305.5 ± 156.9 mIU/L p < 0.001); and in males with MS (358.0 ± 180.0 mIU/L) compared to male controls (182.3 ± 107.5 mIU/L; p < 0.001). Our findings provided more evidence to support the hypothesis that patients with RRMS, regardless of gender, are in a hyperprolactinemic state.
Insights
Elevated prolactin (PRL) levels are linked to multiple sclerosis (MS). This study found significantly higher serum PRL in relapsing-remitting MS patients compared to healthy controls, supporting hyperprolactinemia
Area of Science:
- Neurology
- Endocrinology
- Immunology
Background:
- Hyperprolactinemia, a condition of elevated serum prolactin, is a potential factor in the development of multiple sclerosis (MS).
- Understanding the relationship between prolactin and MS pathogenesis is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the association between serum prolactin levels and relapsing-remitting multiple sclerosis (RRMS).
- To determine if RRMS patients exhibit higher prolactin concentrations compared to healthy individuals.
Main Methods:
- A case-control study was conducted involving 58 patients with definite RRMS during relapse and 58 age- and sex-matched healthy controls.
- Serum prolactin (PRL) concentrations were measured in all participants.
Main Results:
- Patients with RRMS showed significantly higher mean serum PRL levels (501.3 ± 232.6 mIU/L) compared to healthy controls (233.3 ± 142.7 mIU/L; p < 0.0001).
- This hyperprolactinemic state was observed in both females with MS and males with MS when compared to their respective controls.
- Specifically, females with MS had higher PRL (704.4 ± 119.6 mIU/L) than female controls (305.5 ± 156.9 mIU/L; p < 0.001), and males with MS had higher PRL (358.0 ± 180.0 mIU/L) than male controls (182.3 ± 107.5 mIU/L; p < 0.001).
Conclusions:
- The findings provide strong evidence supporting the hypothesis that patients with RRMS experience a hyperprolactinemic state.
- Elevated prolactin levels appear to be a characteristic feature of RRMS, irrespective of gender.
