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Published on: September 7, 2022
Interhemispheric transfer time in patients with auditory hallucinations: an auditory event-related potential study
Katherine R Henshall1, Alex A Sergejew, Colette M McKay
1The Department of Otolaryngology, University of Melbourne, Australia. k.henshall@unimelb.edu.au
Summary
Auditory processing differs in schizophrenia patients. Interhemispheric Transfer Times (IHTTs) for words, not tones, revealed abnormalities in auditory hallucination (AH) and non-AH schizophrenia groups compared to controls.
Area of Science:
- Neuroscience
- Psychiatry
- Auditory Neuroscience
Background:
- Schizophrenia is associated with impaired central auditory processing.
- Abnormalities in interhemispheric transfer are implicated in schizophrenia patients with auditory hallucinations.
Purpose of the Study:
- To investigate interhemispheric functional connectivity between auditory cortical regions in schizophrenia patients.
- To compare Interhemispheric Transfer Times (IHTTs) in patients with and without a history of auditory hallucinations (AH) versus normal controls.
Main Methods:
- EEG recording during monaural presentation of pure tones and single-syllable words.
- Calculation of IHTT using latency measures of the auditory N1 evoked potential.
- Comparison of IHTTs across three groups: AH schizophrenia, non-AH schizophrenia, and normal controls.
Main Results:
- No significant differences in IHTTs for pure tone stimuli between groups.
- Significant differences in IHTTs for word stimuli across the three groups.
- Normal controls showed IHTT near zero; AH group had the highest IHTT; non-AH group exhibited negative IHTT.
Conclusions:
- Findings suggest potential transcallosal dysfunction in schizophrenia patients with auditory hallucinations.
- Altered or reversed cerebral lateralization may be present in schizophrenia patients without a history of auditory hallucinations.
- IHTT differences for complex auditory stimuli (words) may reflect distinct neural processing abnormalities in schizophrenia subtypes.
