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Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology

N V Murthy¹, H Mahncke, B E Wexler

¹Neurosciences CEDD, GlaxoSmithKline R&D, New Frontier Science Park, Harlow, UK. venkatesha.murthy@takeda.com

Schizophrenia Research

|February 21, 2012

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This summary is machine-generated.

The Brain Fitness Program (BFP) showed significant improvements in auditory processing speed but did not generalize to broader cognitive or functional gains in schizophrenia patients. Further research is needed to validate non-pharmacological cognitive interventions.

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Cognitive impairment is a core symptom of schizophrenia, significantly impacting daily functioning.
Previous single-site studies suggested the Brain Fitness Program (BFP) could ameliorate cognitive deficits.
Replication in diverse settings is crucial to validate potential non-pharmacological treatments for schizophrenia.

Purpose of the Study:

To evaluate the efficacy of the Brain Fitness Program (BFP) in improving cognitive performance and functional capacity in stable adult patients with schizophrenia.
To assess the feasibility of implementing BFP training in a multi-site, multinational clinical trial setting.

Main Methods:

An open-label, multi-site, multinational clinical trial involving 55 stable adult patients with schizophrenia.

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Participants completed at least 32 BFP training sessions over 8-10 weeks.

Cognitive performance and functional capacity were assessed using the CogState® schizophrenia battery, UCSD Performance based Skills Assessment (UPSA-2), and Cognitive Assessment Interview (CAI).

Main Results:

BFP training demonstrated a large, significant effect on the auditory processing speed training task.
This improvement did not generalize to enhanced performance on independent CogState® assessments.
No significant improvements were observed in functional capacity measures (UPSA-2, CAI).

Conclusions:

The study confirmed the feasibility of conducting multi-site trials with the Brain Fitness Program (BFP) in schizophrenia patients.
Despite significant effects on a specific training task, BFP did not yield generalized cognitive or functional improvements in this population.
The findings suggest that BFP may not be an effective non-pharmacological intervention for broad cognitive amelioration in schizophrenia.