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Related Experiment Video

Updated: May 24, 2026

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Targeting protein lipidation in disease.

Marilyn D Resh¹

¹Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA. m-resh@ski.mskcc.org

Trends in Molecular Medicine

|February 21, 2012

Summary

Lipid modifications like myristoylation and prenylation regulate proteins. Inhibitors targeting these processes show potential for treating infectious diseases, cancer, and rare aging syndromes.

Area of Science:

Biochemistry
Molecular Biology
Medicinal Chemistry

Background:

Lipid modifications (fatty acids, isoprenoids) are crucial for protein function.
These modifications regulate protein structure, localization, and activity.
Dysregulation of protein lipidation is implicated in various human diseases.

Purpose of the Study:

To review recent advancements in identifying protein lipidation inhibitors.
To explore the therapeutic potential of these inhibitors in human diseases.
To highlight novel agents targeting specific lipid modification pathways.

Main Methods:

Literature review of recent research on protein lipidation inhibitors.
Analysis of studies investigating the effects of inhibitors on disease models.

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Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

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Lipidomics and Transcriptomics in Neurological Diseases

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Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

Published on: April 9, 2021

Identification of key protein lipidation pathways and their targeted inhibitors.

Main Results:

Myristoylation inhibitors demonstrate efficacy against human pathogens.
Prenylation inhibitors show limited success in cancer but potential for progeria.
New agents targeting palmitoylation of Ras, Wnt, and Hh proteins have emerged.

Conclusions:

Inhibitors of protein lipidation represent a promising therapeutic strategy.
Targeting myristoylation, prenylation, and palmitoylation offers diverse treatment possibilities.
Further development of these agents could lead to next-generation chemotherapeutics.