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Immunostaining to Visualize Murine Enteric Nervous System Development
07:54

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

Cell death and the developing enteric nervous system.

Alcmène Chalazonitis1, Michael D Gershon, Lloyd A Greene

  • 1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA. ac83@columbia.edu

Neurochemistry International
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Cell death in the developing enteric nervous system (ENS) is crucial for gut function. Unlike other neural areas, the ENS exhibits minimal fetal apoptotic death, suggesting unique survival mechanisms and implications for gastrointestinal disorders.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Gastroenterology

Background:

  • The developing enteric nervous system (ENS) is critical for gastrointestinal function.
  • Cell death, particularly apoptosis, is a key process in neural development.
  • Understanding ENS development is vital for addressing gastrointestinal disorders.

Purpose of the Study:

  • To review current knowledge on cell death in the developing ENS.
  • To explore the molecular mechanisms underlying ENS cell death.
  • To discuss factors influencing ENS cell survival and death.

Main Methods:

  • Literature review of studies on ENS development and cell death.
  • Analysis of molecular mechanisms and genetic factors involved in ENS cell death.
  • Comparison of ENS development with other central and peripheral nervous systems.

Main Results:

  • Enteric neural crest-derived precursor cells undergo significant apoptotic death en route to the gut.
  • Once in the gut, precursor cells, neurons, and glia show limited death during the fetal period.
  • ENS development differs from other neural systems with substantial fetal apoptotic death.

Conclusions:

  • The ENS exhibits a unique pattern of cell death during development compared to other neural systems.
  • A supportive fetal enteric microenvironment may contribute to reduced cell death.
  • Abnormalities in ENS cell survival and death mechanisms are implicated in gastrointestinal disorders like Hirschsprung's disease.