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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

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Published on: November 19, 2012

Structure-function associations in hippocampus in bipolar disorder.

Lara G Chepenik1, Fei Wang, Linda Spencer

  • 1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.

Biological Psychology
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Bipolar disorder (BD) is linked to smaller hippocampus volumes and verbal memory deficits. This study found a correlation between reduced hippocampus size and memory impairment in BD patients, suggesting potential treatment avenues.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Bipolar disorder (BD) is independently associated with hippocampus volume reduction and verbal memory deficits.
  • The relationship between these two common observations in BD remains unclear.

Purpose of the Study:

  • To investigate the association between hippocampus volume and verbal memory function in individuals with bipolar disorder.
  • To explore potential correlations between brain structure and cognitive performance in BD.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to measure hippocampus volumes in 31 subjects with BD and 32 healthy comparison (HC) subjects.
  • Verbal memory was assessed using the California Verbal Learning Test-Second Edition (CVLT).

Main Results:

  • Subjects with BD exhibited significantly smaller hippocampus volumes compared to HC subjects.
  • The BD group demonstrated impaired performance on multiple verbal memory recall tasks (immediate, short delay, long delay).
  • A significant correlation was found between smaller hippocampus volume and poorer verbal memory performance in BD patients.

Conclusions:

  • Structural changes in the hippocampus are associated with verbal memory impairments in bipolar disorder.
  • Preliminary evidence suggests that antidepressant pharmacotherapy may potentially reverse hippocampus-related memory deficits in BD.