Related Experiment Video
Updated: May 24, 2026
07:42
A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
Published on: June 5, 2014
Pulmonary sequestration with tuberculosis confined to the sequestrated lung
Xiaoying Huang1, Xiaomei Xu, Chang Yu
1Division of Pulmonary Medicine, Frist Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China.
Summary
Pulmonary sequestration, a rare lung malformation, can mimic pneumonia. This case highlights the importance of considering sequestration in persistent lower lobe infiltrates and investigating co-existing conditions like tuberculosis.
Area of Science:
- Pulmonology
- Radiology
- Pathology
Background:
- Pulmonary sequestration is a rare congenital lung malformation with a high incidence of pyogenic infection.
- Misdiagnosis is common, often presenting as recurrent or persistent pneumonia, particularly in the lower lobes.
Observation:
- A 19-year-old male presented with a misdiagnosed left lower lobe infiltrate, initially treated as pneumonia.
- Contrast-enhanced CT revealed an aberrant artery supplying the affected lobe, indicative of pulmonary sequestration.
- Microscopic examination of the resected lobe showed caseous necrosis with Langhans cells, confirming co-existing tuberculosis confined to the sequestrum.
Findings:
- Surgical removal of the sequestrated lobe and subsequent antituberculous chemotherapy led to an excellent clinical outcome.
- This case underscores the diagnostic challenge of pulmonary sequestration, especially when presenting atypically.
- The presence of tuberculosis within the sequestration highlights the need for thorough investigation beyond the primary diagnosis.
Implications:
- Persistent lower lobe infiltrates should raise suspicion for pulmonary sequestration.
- Accurate diagnosis of pulmonary sequestration requires advanced imaging and consideration of co-morbidities.
- Integrated management involving surgery and chemotherapy is crucial for favorable outcomes in complicated cases of pulmonary sequestration with tuberculosis.
Related Concept Videos
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:27Pneumothorax-II
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations: