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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...

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Personalized medicine: a personal view.

U A Meyer1

  • 1Biozentrum of the University of Basel, Basel, Switzerland. urs-a.meyer@unibas.ch

Clinical Pharmacology and Therapeutics
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Personalized medicine tailors disease prevention, diagnosis, and treatment to individuals. Advances in genomic sequencing reveal genetic diversity

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Area of Science:

  • Genomics
  • Personalized Medicine
  • Translational Science

Background:

  • The human genome sequencing and technological progress have illuminated the vast genetic diversity among individuals.
  • Understanding the interplay between genetic and environmental factors is crucial for human health, disease development, and responses to medications.

Purpose of the Study:

  • To explore the potential of personalized medicine in optimizing individual health outcomes.
  • To address the challenge of translating genomic insights into practical clinical applications.

Main Methods:

  • Review of recent advancements in human genome sequencing.
  • Analysis of the contribution of genetic and non-genetic factors to health and disease.
  • Exploration of strategies for clinical translation of genomic data.

Main Results:

  • Genetic diversity significantly impacts individual health and drug responses.
  • Genomic information provides a basis for tailored medical interventions.
  • Technological advances facilitate the collection and analysis of large-scale genomic data.

Conclusions:

  • Personalized medicine offers a promising approach to improve patient outcomes.
  • Translating genomic discoveries into clinical practice remains a key challenge.
  • Further research is needed to fully realize the benefits of personalized medicine.