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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Previous infection and stroke: a prospective study

Jaume Roquer1, Elisa Cuadrado-Godia, Eva Giralt-Steinthauer

  • 1Department of Neurology, Hospital Universitari del Mar, Parc de Salut Mar, Barcelona, Spain. jroquer@hospitaldelmar.cat

Cerebrovascular Diseases (Basel, Switzerland)
|February 21, 2012
PubMed
Abstract

Insights

Previous infections (PI) occurred in 9.7% of stroke patients, particularly respiratory infections. While PI correlated with stroke severity and poorer functional status, it did not independently impact 3-month outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Infections are suspected triggers for ischemic strokes (IS).
  • This study investigated the frequency and impact of previous infections (PI) on IS and intracerebral hemorrhage (ICH).

Purpose of the Study:

  • To determine the incidence of PI in IS and ICH.
  • To explore associations between PI, stroke subtypes, and patient outcomes.

Main Methods:

  • Prospective study of 1,981 acute stroke patients (Jan 2005-Dec 2010).
  • Assessed PI within one month prior to stroke.
  • Correlated PI with demographics, risk factors, stroke type, and 3-month outcomes.

Main Results:

  • 9.7% of patients had PI; most common were respiratory infections (36.8%) and flu (30.1%).
  • PI was more frequent in IS (10.2%) than ICH (6.8%).
  • For IS, PI was linked to older age, worse prior functional status, increased stroke severity, poorer outcomes, and higher mortality.

Conclusions:

  • PIs are present in 9.7% of stroke cases, with no TOAST subtype differences.
  • PI is associated with poorer prior functional status and stroke severity.
  • PI does not independently influence 3-month stroke outcomes.

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