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Effect of mitomycin C-aided trabeculectomy on conjunctival goblet cell density
S Mukhopadhyay1, S K D Thakur, J Dutta
1Regional Institute of Ophthalmology, School of Tropical Medicine and Hygiene, Kolkata, India.
Summary
Mitomycin C increases trabeculectomy success but harms conjunctival goblet cells. This study shows a significant decrease in goblet cells after mitomycin C use, impacting ocular surface health.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Ocular Surface Disease
Background:
- Mitomycin C is frequently used with trabeculectomy to improve surgical success rates.
- However, its use is linked to sight-threatening complications, necessitating further investigation into its effects.
Purpose of the Study:
- To evaluate the impact of mitomycin C on conjunctival goblet cell density following trabeculectomy.
- To compare the changes in goblet cell population in eyes treated with mitomycin C versus those without.
Main Methods:
- Twenty eyes undergoing trabeculectomy were divided into two groups: Group A (with mitomycin C) and Group B (without antimetabolites).
- Conjunctival impression cytology was performed preoperatively and at 1, 3, 6, 9, and 12 months postoperatively to assess goblet cell density.
Main Results:
- Group A showed a statistically significant decrease in goblet cell density from baseline to 12 months (p < 0.0001).
- In contrast, Group B did not exhibit a statistically significant change in goblet cell density (p = 0.27).
Conclusions:
- Mitomycin C significantly reduces conjunctival goblet cell density after trabeculectomy.
- These findings highlight the detrimental effect of mitomycin C on the ocular surface and suggest potential implications for long-term ocular health.
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