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Updated: May 24, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Use of an automated bolus calculator in MDI-treated type 1 diabetes: the BolusCal Study, a randomized controlled
Signe Schmidt1, Merete Meldgaard, Nermin Serifovski
1Department of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark. signe.schmidt@hvh.regionh.dk
Objective:
To investigate the effect of flexible intensive insulin therapy (FIIT) and an automated bolus calculator (ABC) in a Danish type 1 diabetes population treated with multiple daily injections. Furthermore, to test the feasibility of teaching FIIT in a 3-h structured course.
Research Design And Methods:
The BolusCal Study was a 16-week randomized, controlled, open-label, three-arm parallel, clinical study of 51 adults with type 1 diabetes. Patients aged 18-65 years in poor metabolic control (HbA(1c) 8.0-10.5%) were randomized to the Control (n = 8), CarbCount (n = 21), or CarbCountABC (n = 22) arm. During a 3-h group teaching, the Control arm received FIIT education excluding carbohydrate counting. CarbCount patients were taught FIIT and how to count carbohydrates. CarbCountABC group teaching included FIIT and carbohydrate counting and patients were provided with an ABC.
Results:
At 16 weeks, the within-group change in HbA(1c) was -0.1% (95% CI -1.0 to 0.7%; P = 0.730) in the Control arm, -0.8% (-1.3 to -0.3%; P = 0.002) in the CarbCount arm, and -0.7% (-1.0 to -0.4%; P < 0.0001) in the CarbCountABC arm. The difference in change in HbA(1c) between CarbCount and CarbCountABC was insignificant. Adjusting for baseline HbA(1c) in a regression model, the relative change in HbA(1c) was -0.6% (-1.2 to 0.1%; P = 0.082) in CarbCount and -0.8% (-1.4 to -0.1%; P = 0.017) in CarbCountABC. Treatment satisfaction measured by the Diabetes Treatment Satisfaction Questionnaire (status version) improved in all study arms, but the improvement was significantly greater in CarbCountABC.
Conclusions:
FIIT and carbohydrate counting were successfully taught in 3 h and improved metabolic control and treatment satisfaction. Concurrent use of an ABC improved treatment satisfaction further.
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