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A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission
Nicholas R Conley1, Anca Dragulescu-Andrasi, Jianghong Rao
1Department of Chemistry, Stanford University, CA 94305-5080, USA.
Angewandte Chemie (International Ed. in English)
|February 21, 2012
Abstract:
A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects.
