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Single-nucleotide polymorphisms in the KDR gene in pregnancies complicated by gestational hypertensive disorders and

Prabha H Andraweera1, Gustaaf A Dekker, Steven D Thompson

  • 1Discipline of Obstetrics and Gynaecology, Robinson Institute, University of Adelaide, Australia.

Reproductive Sciences (Thousand Oaks, Calif.)
|February 21, 2012
PubMed

Insights

Paternal and neonatal KDR gene variations are linked to increased risks of preeclampsia and small-for-gestational-age (SGA) infants. This finding highlights genetic factors in pregnancy complications and future cardiovascular disease risk.

Area of Science:

  • Obstetrics and Gynecology
  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • Preeclampsia and small-for-gestational-age (SGA) infants share placental vascular issues and increase later coronary artery disease risk.
  • Kinase insert domain receptor (KDR) is crucial for placental vascular development.
  • KDR gene polymorphisms (-604T/C and Val297Ile) are linked to coronary artery disease.

Purpose of the Study:

  • To investigate the association of KDR gene polymorphisms (-604T/C and Val297Ile) with preeclampsia, gestational hypertension, and SGA.
  • To explore the role of KDR gene variations in pregnancy complications.

Main Methods:

  • Prospective cohort study of 1169 nulliparous women, partners, and infants.
  • Doppler ultrasound of uterine and umbilical arteries at 20 weeks gestation.
  • Genotyping of KDR polymorphisms using Sequenom MassARRAY and logistic regression analysis.

Main Results:

  • In 937 Caucasian pregnancies, KDR-604T/C polymorphism in fathers and neonates was associated with preeclampsia.
  • Paternal and neonatal KDR-604T/C also showed association with SGA infants.
  • Associations were observed for SGA with abnormal Doppler findings.

Conclusions:

  • Paternal and neonatal carriage of the KDR-604T/C polymorphism increases the risk of preeclampsia.
  • The KDR-604T/C polymorphism is associated with the risk of developing SGA infants.
Abstract

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