Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-linked Traits01:19

X-linked Traits

58.9K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.9K
Sex-linked Disorders01:43

Sex-linked Disorders

109.2K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
109.2K
Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal gene panel selection for targeted spatial transcriptomics experiments.

Nucleic acids research·2026
Same author

Optimal Gene Panel Selection for Targeted Spatial Transcriptomics Experiments.

bioRxiv : the preprint server for biology·2025
Same author

SpaDiff: Denoising for Sequence-based Spatial Transcriptomics via Diffusion Process.

bioRxiv : the preprint server for biology·2025
Same author

sCCIgen: a high-fidelity spatially resolved transcriptomics data simulator for cell-cell interaction studies.

Genome biology·2025
Same author

Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem.

Nature methods·2025
Same author

QuadST identifies cell-cell interaction-changed genes in spatially resolved transcriptomics data.

Genome research·2025
Same journal

Tools for computational analysis of moving boundary problems in cellular mechanobiology.

Wiley interdisciplinary reviews. Systems biology and medicine·2020
Same journal

Cellular reprogramming: Mathematics meets medicine.

Wiley interdisciplinary reviews. Systems biology and medicine·2020
Same journal

Thermoregulation: A journey from physiology to computational models and the intensive care unit.

Wiley interdisciplinary reviews. Systems biology and medicine·2020
Same journal

Mammalian cell and tissue imaging using Raman and coherent Raman microscopy.

Wiley interdisciplinary reviews. Systems biology and medicine·2020
Same journal

Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves".

Wiley interdisciplinary reviews. Systems biology and medicine·2020
Same journal

Molecular networks in Network Medicine: Development and applications.

Wiley interdisciplinary reviews. Systems biology and medicine·2020
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

2.5K

Linking genome to epigenome.

Guo-Cheng Yuan1

  • 1Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA. gcyuan@jimmy.harvard.edu

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Genomic sequence plays a key role in establishing and maintaining the epigenome across different cell types and developmental stages. Understanding these sequence-epigenetic interactions is crucial for deciphering cellular identity.

More Related Videos

Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

1.7K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

Related Experiment Videos

Last Updated: Feb 11, 2026

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

2.5K
Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

1.7K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

Area of Science:

  • Epigenetics and genomics
  • Developmental biology
  • Cellular differentiation

Background:

  • Epigenomic studies reveal significant variations across developmental stages and cell types.
  • The mechanisms underlying the establishment and maintenance of global epigenetic patterns are not fully understood.
  • Epigenetic regulation is increasingly recognized for its importance in biological processes.

Purpose of the Study:

  • To review recent studies focusing on the role of genomic sequence in shaping the epigenetic landscape.
  • To emphasize how sequence information influences epigenetic pattern diversity among cell types.
  • To highlight the need for integrative approaches to understand epigenome maintenance.

Main Methods:

  • Review of recent epigenomic studies.
  • Analysis of the role of genomic sequence in epigenetic pattern determination.
  • Synthesis of findings on epigenetic regulation and maintenance.

Main Results:

  • Genomic sequence is crucial for controlling target specificity of epigenetic regulators.
  • Sequence information orchestrates the diversity of epigenetic patterns observed in different cell types.
  • The epigenome is maintained through a complex network of interactions.

Conclusions:

  • Genomic sequence is a fundamental determinant of the epigenetic landscape.
  • Understanding sequence-epigenetic interplay is key to explaining cell-type-specific epigenomes.
  • Integrative, network-based approaches are essential for future research in epigenome maintenance.