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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

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Related Experiment Video

Updated: May 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

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The transcription factor c-Maf controls touch receptor development and function.

Hagen Wende1, Stefan G Lechner, Cyril Cheret

  • 1Developmental Biology, Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.

Science (New York, N.Y.)
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

The transcription factor c-Maf is essential for touch sensation. Its mutation disrupts mechanoreceptor development and function, affecting high-frequency vibration detection in mice and humans.

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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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Published on: March 15, 2019

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The sense of touch involves mechanosensory neurons detecting mechanical stimuli.
  • Limited molecular data hinders understanding of mechanoreceptor development, diversity, and function.

Purpose of the Study:

  • To investigate the role of the transcription factor c-Maf in mechanosensory function.
  • To identify key molecular players in mechanoreceptor development and diversity.

Main Methods:

  • Analysis of c-Maf mutant mice to study mechanoreceptor development and function.
  • Assessment of Pacinian corpuscle morphology and high-frequency vibration sensitivity.
  • Examination of human subjects with c-MAF gene mutations.

Main Results:

  • c-Maf is crucial for mechanosensory function in mice and humans.
  • Development and function of rapidly adapting mechanoreceptors, including Pacinian corpuscles, are disrupted in c-Maf mutant mice.
  • Pacinian corpuscles are atrophied in c-Maf mutant mice, correlating with reduced high-frequency vibration sensitivity in humans with c-MAF mutations.

Conclusions:

  • The transcription factor c-Maf is a key regulator of mechanoreceptor development and function.
  • c-Maf specifies the development and function of mechanoreceptors and their associated end organs.
  • This finding provides molecular insight into the basis of touch sensation diversity and function.