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Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pneumothorax-II01:27

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

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Related Experiment Video

Updated: May 24, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Malignant pleural mesothelioma.

Sheree E Chen, Makala B Pace

    American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
    |February 21, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Newer chemotherapy regimens, particularly pemetrexed and platinum combinations, have improved outcomes for malignant pleural mesothelioma (MPM). These advancements offer better tumor response and survival rates for this asbestos-related cancer.

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    Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
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    Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

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    Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
    09:31

    Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

    Published on: October 2, 2015

    Area of Science:

    • Oncology
    • Thoracic Surgery
    • Medical Oncology

    Background:

    • Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer.
    • Approximately 70% of MPM cases are linked to asbestos exposure.
    • MPM typically requires a multimodal treatment approach.

    Purpose of the Study:

    • To review the etiology, diagnosis, staging, and management of MPM.
    • To emphasize clinical trials of novel first-line, second-line, and adjuvant chemotherapy strategies.

    Main Methods:

    • Review of clinical trials and treatment approaches for MPM.
    • Analysis of chemotherapy regimens, including combination therapies.
    • Evaluation of surgical and radiotherapeutic interventions.

    Main Results:

    • The combination of cisplatin or carboplatin with pemetrexed shows high tumor response rates (21-41%) and improved overall survival (12-14 months).
    • Neoadjuvant chemotherapy followed by surgery may lead to longer survival (up to 23-29 months), but requires further validation.
    • Other agents like gemcitabine and vinorelbine have variable efficacy.

    Conclusions:

    • Recent advances in chemotherapy, especially pemetrexed and platinum combinations, have improved MPM treatment outcomes.
    • MPM continues to carry a poor prognosis despite therapeutic advancements.
    • Further research is needed to define the optimal role of neoadjuvant therapy.