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Updated: May 24, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I
Daniel Salamon1, Monika Adori, Dorina Ujvari
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Daniel.Salamon@ki.se
Abstract:
We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients.
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