Related Experiment Video
Updated: May 24, 2026

In vitro Measurements of Tracheal Constriction Using Mice
Published on: June 25, 2012
Chloride in airway smooth muscle: the ignored anion no longer?
George Gallos1, Peter Yim, Charles W Emala
1Department of Anesthesiology, Columbia University, New York, New York 10032, USA. gg2125@columbia.edu
Abstract:
This Perspectives accompanies an Editorial Focus that summarizes new developments concerning the role of chloride in airway smooth muscle physiology. We provide several observations and mechanistic insights to reconcile recent experimental evidence with existing paradigms concerning chloride channel-mediated effects on airway smooth muscle tone. In addition, we highlight the potentially complex and dynamic nature that chloride currents and membrane potential have on calcium handling and airway smooth muscle contractility.
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