Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Test Cross01:39

Test Cross

43.9K
Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
43.9K
Dihybrid Crosses01:18

Dihybrid Crosses

80.9K
Overview
80.9K
Multiple Allele Traits01:49

Multiple Allele Traits

38.0K
The Concept of Multiple Allelism
38.0K
Trihybrid Crosses02:27

Trihybrid Crosses

25.3K
Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal...
25.3K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

76.0K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
76.0K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.7K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive analysis of mitophagy-related genes reveals prognostic signatures in breast cancer: based on immune landscapes and treatment target predict.

Frontiers in immunology·2026
Same author

PETScan: score-based genome-wide association analysis of RNA-Seq and ATAC-Seq data.

Bioinformatics (Oxford, England)·2026
Same author

Combined developmental toxicity of organophosphorus flame retardant TCEP and lead on zebrafish.

Ecotoxicology and environmental safety·2026
Same author

Epigenetic Age Acceleration and Hearing Function in US Older Adults.

Ear and hearing·2026
Same author

Treponema pallidum lipoprotein Tp0768 promotes H3K18 Lactylation modification to target PTK2 and enhance endothelial permeability.

International immunopharmacology·2026
Same author

Study on the effects of zirconia restorations in oral prosthodontics on inflammatory factor levels and masticatory function.

Medicine·2026

Related Experiment Video

Updated: Jan 19, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

821

Varying coefficient models for mapping quantitative trait loci using recombinant inbred intercrosses.

Yi Gong1, Fei Zou

  • 1Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Genetics
|February 21, 2012
PubMed
Summary

This study introduces a new nonparametric method for mapping quantitative trait loci (QTL) in recombinant inbred intercrosses (RIX) mice. The method effectively models how genetic effects change over time, improving QTL mapping precision for complex traits.

More Related Videos

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.6K
Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.8K

Related Experiment Videos

Last Updated: Jan 19, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

821
Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.6K
Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.8K

Area of Science:

  • Genetics
  • Statistical Genomics
  • Bioinformatics

Background:

  • Quantitative trait loci (QTL) mapping is crucial for understanding complex traits.
  • Experimental crosses, like those using the Collaborative Cross (CC) mouse resource, generate valuable data for QTL analysis.
  • Recombinant inbred intercrosses (RIX) offer advantages over traditional F(2) crosses but require advanced statistical methods due to unbalanced genetic relatedness.

Purpose of the Study:

  • To develop a flexible nonparametric method for time-varying quantitative trait loci (QTL) mapping specifically for recombinant inbred intercrosses (RIX) data.
  • To address the challenge of complex traits where genetic effects may change over time or with other covariates.
  • To improve the power and precision of QTL detection in RIX populations.

Main Methods:

  • Proposed a nonparametric time-varying coefficient QTL mapping method utilizing B-spline bases.
  • Modeled evolving genetic effects to investigate gene-by-time interactions in RIX data.
  • Employed a modified permutation procedure for controlling the overall significance level.

Main Results:

  • The proposed nonparametric method demonstrated higher power and mapping precision compared to traditional parametric models when genetic effects are not constant.
  • The method successfully models dynamic genetic patterns and gene-by-time interactions.
  • Simulation results validated the effectiveness of the new approach.

Conclusions:

  • The developed nonparametric time-varying coefficient QTL mapping method offers a flexible and powerful approach for analyzing RIX data.
  • This method enhances the ability to study complex traits with dynamic genetic architectures.
  • It provides a valuable tool for genetic research in animal and plant sciences using advanced mouse models.