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Updated: May 24, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
DOMIRE: a web server for identifying structural domains and their neighbors in proteins
Franck Samson1, Richard Shrager, Chin-Hsien Tai
1Institut National de la Recherche Agronomique, UR1077, Unité Mathématique, Informatique et Génome, 78350 Jouy-en-Josas, France.
Summary:
The DOMIRE web server implements a novel, automatic, protein structural domain assignment procedure based on 3D substructures of the query protein which are also found within structures of a non-redundant protein database. These common 3D substructures are transformed into a co-occurrence matrix that offers a global view of the protein domain organization. Three different algorithms are employed to define structural domain boundaries from this co-occurrence matrix. For each query, a list of structural neighbors and their alignments are provided. DOMIRE, by displaying the protein structural domain organization, can be a useful tool for defining protein common cores and for unravelling the evolutionary relationship between different proteins.
Availability:
http://genome.jouy.inra.fr/domire
Contact:
jean.garnier@jouy.inra.fr.
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