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Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

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Increased atherothrombotic markers and endothelial dysfunction in steroid users.

Cátia B Severo¹, Jorge P Ribeiro, Daniel Umpierre

¹Exercise Pathophysiology Research Laboratory (LaFiEx) and Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

European Journal of Preventive Cardiology

|February 21, 2012

Summary

Androgenic anabolic steroid (AAS) users exhibit elevated cardiovascular risk markers and impaired endothelial function compared to non-users. This study highlights significant changes in lipids, inflammation, and blood vessel function in AAS users.

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Area of Science:

Cardiovascular Science
Endocrinology
Sports Medicine

Background:

Androgenic anabolic steroid (AAS) use is linked to potential atherothrombotic and endothelial function alterations.
Understanding these effects is crucial for assessing cardiovascular health in AAS users.

Purpose of the Study:

To compare atherothrombotic markers and endothelial function between AAS users and non-users.
To evaluate the impact of AAS on cardiovascular risk factors.

Main Methods:

Cross-sectional study comparing 10 AAS users and 12 non-user athletes.
Evaluated body mass, blood pressure, CBC, platelets, fibrinogen, lipids, hs-CRP, hormones, and endothelial function via brachial artery ultrasound.

Main Results:

AAS users showed higher body mass, blood pressure, platelets, and hs-CRP.
AAS users had lower HDL-cholesterol and suppressed follicle-stimulating hormone.
Endothelium-dependent function (flow-mediated dilation) was reduced in AAS users, correlating positively with HDL-cholesterol.

Conclusions:

AAS users display altered blood lipids and inflammatory markers, indicating increased cardiovascular risk.
AAS use is associated with impaired endothelial function.
These findings underscore the cardiovascular implications of AAS consumption.