Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury
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Updated: May 24, 2026

Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection
Published on: July 21, 2022
Susanne Herold1, Stephan Ludwig, Stephan Pleschka
1University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany. susanne.herold@innere.med.uni-giessen.de
Abstract:
Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.
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