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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

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SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Senescence (ageing) @ 2011.

Anjana Nigam1

  • 1Department of Surgery, Pt. J. N. M. Medical College, Raipur, CG, India .

Indian Journal of Dermatology
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Aging, or senescence, is a complex biological process impacting organismal function. Genetic factors like sirtuins and pathways such as insulin/IGF-1 influence aging speed and stress resistance, guiding anti-aging medicine development.

Keywords:
Gene regulationinflammagingpathwaysproteinssenescencetherapy

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Last Updated: May 24, 2026

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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Area of Science:

  • Gerontology
  • Molecular Biology
  • Genetics

Background:

  • Aging (senescence) is a complex biological process characterized by declining organismal function.
  • Factors influencing aging include telomerase, environment, diet, free radicals, and genetic components.
  • Understanding aging pathophysiology is crucial for developing targeted anti-aging therapies.

Purpose of the Study:

  • To review the known genetic and molecular mechanisms regulating the aging process.
  • To highlight the role of specific genes (e.g., sirtuins) and pathways (e.g., insulin/IGF-1) in aging.
  • To identify future research directions for anti-aging medicine.

Main Methods:

  • Review of existing literature on aging mechanisms.
  • Identification of key genes, pathways, and cellular processes involved in senescence.
  • Analysis of factors contributing to organismal resistance to stress and damage.

Main Results:

  • Sirtuin genes and the insulin/insulin-like growth factor 1 pathway are key regulators of aging speed and stress resistance.
  • Apoptosis, p53 activity, and autophagy can trigger premature aging.
  • Aging upregulates inflammatory mediators in adipose tissue.

Conclusions:

  • Aging is a multifactorial process influenced by genetics, cellular mechanisms, and inflammation.
  • Targeted therapies for aging require further research into systemic inflammatory markers and gene signaling pathways.
  • Development of animal and human models is essential for evaluating potential anti-aging interventions.