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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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Primary cutaneous leiomysarcoma.

Shubhangi Vinayak Agale1, Sumit Grover, Rahul Zode

  • 1Department of Pathology, Grant Medical College, Mumbai, India .

Indian Journal of Dermatology
|February 21, 2012
PubMed
Summary

Primary cutaneous leiomyosarcoma is a rare skin cancer. This study details a case, highlighting its histological and immunohistochemical features for better understanding and diagnosis of this uncommon soft tissue neoplasm.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Primary cutaneous leiomyosarcoma (PCL) is a rare soft tissue neoplasm, representing 2-3% of superficial soft tissue sarcomas.
  • Typically affects individuals aged 50-70 years, with a predilection for lower extremities.
  • Characterized clinically by solitary, well-circumscribed nodules and microscopically by fascicles of spindle cells with cigar-shaped nuclei.

Purpose of the Study:

  • To document a case of primary cutaneous leiomyosarcoma in an elderly male.
  • To discuss the histological features and immunohistochemical profile of this uncommon neoplasm.
  • To enhance understanding and diagnostic accuracy for PCL.

Main Methods:

  • Case report of a 77-year-old male patient.
  • Detailed histological examination of the tumor.
Keywords:
Cutaneousleiomyosarcomasmooth muscle

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  • Immunohistochemical analysis to characterize the neoplastic cells.

    • Main Results:

    • The case presented as a primary cutaneous leiomyosarcoma in an elderly patient.
    • Histological findings confirmed the characteristic features of leiomyosarcoma.
    • Immunohistochemistry provided a detailed profile of the tumor's cellular markers.

    Conclusions:

    • Primary cutaneous leiomyosarcoma is an uncommon but distinct entity.
    • Accurate histological and immunohistochemical evaluation is crucial for diagnosis.
    • Understanding its features aids in managing local recurrence and patient care.