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Updated: May 24, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Published on: November 1, 2015

Congenital lupus erythematosus.

Taseer Ahmed Bhatt1, Hanadi A Fatani, Samara Mimesh

  • 1Department of Internal Medicine, Dermatology Division, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia .

Indian Journal of Dermatology
|February 21, 2012
PubMed
Summary

Neonatal lupus erythematosus (NLE) can present unusually at birth with skin lesions and thrombocytopenia. This rare autoimmune condition, caused by maternal anti-Ro antibodies, requires careful diagnosis in newborns.

Keywords:
Atrophic lesionsSaudi Arabiacongenital lupus erythematosus

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Area of Science:

  • Dermatology
  • Pediatrics
  • Immunology

Background:

  • Neonatal lupus erythematosus (NLE) is a rare autoimmune condition in infants.
  • It results from transplacental transfer of maternal anti-Ro autoantibodies.
  • Typical NLE manifestations include subacute cutaneous lupus erythematosus appearing months after birth.

Purpose of the Study:

  • To report a rare case of NLE presenting at birth with atypical skin manifestations.
  • To highlight the importance of considering NLE in neonates with unexplained skin conditions and thrombocytopenia.

Main Methods:

  • Clinical case presentation of a neonate with congenital skin lesions.
  • Laboratory investigations including serology for anti-Ro autoantibodies (extranuclear antigens).
  • Histopathological examination of skin biopsy.

Main Results:

  • The infant presented at birth with scaly, erythematous, telangiectatic patches and macules with skin atrophy on the face, head, and upper trunk.
  • Thrombocytopenia was detected in the neonate.
  • Skin biopsy confirmed subacute cutaneous lupus erythematosus; serology was positive for anti-Ro autoantibodies in both infant and mother, who was asymptomatic.

Conclusions:

  • This case demonstrates an unusual congenital presentation of NLE.
  • It underscores the variability of NLE and the need for high clinical suspicion, even in the absence of maternal autoimmune history.
  • Early diagnosis and management are crucial for affected infants.