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Related Concept Videos

Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Halogens03:01

Halogens

Group 17 elements, known as halogens, are nonmetals. At room temperature, fluorine and chlorine are gases, bromine is a liquid, and iodine a solid. Astatine is a highly unstable radioactive element, so currently, most of its properties are unknown due to its short half-life. Tennessine is a synthetic element also predicted to be in this group.
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A key...

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Related Experiment Video

Updated: May 24, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Desflurane - revisited.

Mukul Chandra Kapoor1, Mahesh Vakamudi

  • 1Department of Anaesthesiology, Pushpanjali Crosslay Hospital, Ghaziabad, Uttar Pradesh, India.

Journal of Anaesthesiology, Clinical Pharmacology
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Desflurane offers precise anesthesia control and rapid recovery, making it a valuable agent for various patients and surgeries. Cost-effective methods like low-flow anesthesia are recommended to mitigate increased direct anesthetic care costs.

Keywords:
Anestheticsdesfluraneinhalationallow-flow anesthesia

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • The ongoing pursuit of an ideal inhalational general anesthetic agent.
  • Desflurane's recent introduction to the Indian market.

Purpose of the Study:

  • To evaluate desflurane as a potential ideal anesthetic agent.
  • Highlighting its pharmacokinetic and pharmacodynamic advantages.

Main Methods:

  • Clinical evaluation of desflurane's properties.
  • Assessment of recovery characteristics and patient outcomes.

Main Results:

  • Desflurane demonstrates favorable pharmacokinetics and pharmacodynamics.
  • Enables precise anesthesia depth control and rapid, clear-headed recovery.
  • Beneficial in extremes of age and obese patients.

Conclusions:

  • Desflurane is a valuable agent for anesthesia maintenance in diverse surgical settings.
  • Potential for increased direct costs necessitates cost-saving techniques like low-flow anesthesia.
  • Consideration of environmental implications is advised.