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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
The Tumor Microenvironment02:17

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Related Experiment Video

Updated: May 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Inflammatory myofibroblastic tumor.

Sangeeta Palaskar1, Supriya Koshti, Mahesh Maralingannavar

  • 1Department of Oral Pathology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India.

Contemporary Clinical Dentistry
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

Inflammatory myofibroblastic tumors, also known as inflammatory pseudotumors, are rare growths with uncertain origins. Recent evidence suggests they may have neoplastic potential, challenging the notion of them being purely reactive lesions.

Keywords:
ALK-1myofibroblastsneoplasticreactive

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Published on: May 17, 2024

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Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion characterized by myofibroblastic proliferation and inflammatory infiltrate.
  • Numerous synonyms exist, reflecting uncertainty about its biologic nature, including inflammatory pseudotumor and plasma cell granuloma.

Purpose of the Study:

  • To report a case of inflammatory pseudotumor.
  • To review the inflammatory versus neoplastic behavior of these lesions.

Main Methods:

  • Case report presentation.
  • Literature review on inflammatory myofibroblastic tumors.

Main Results:

  • The diverse nomenclature highlights diagnostic challenges.
  • Clinical recurrence and metastasis, along with cytogenetic evidence of clonal abnormalities, challenge the reactive nature of IMT.

Conclusions:

  • The biologic nature of IMT remains debated, with growing evidence supporting neoplastic potential.
  • Further research is needed to clarify the behavior and classification of inflammatory myofibroblastic tumors.